Biosensors and Bioelectronics: X 2022, 12, 100235. Recent advances in the electrochemical sensing of lung cancer biomarkers. Vijayan, Lavanya Jothi, Ravi Sankar Arunagirinathan, Gomathi Nageswaran. Detection of Acetylcholine at Nanoscale NPOE/Water Liquid/Liquid Interface Electrodes. Milton, Edappalil Satheesan Anupriya, Ran Chen, Kerui Xu, Mei Shen. This article is cited by 13 publications. Thus, the CSNPs-based electrochemical sensor platform has high potential for developing a simple, cost-effective biosensor for early detection of cancer biomarker at nanomolar concentration. The limit of detection of ACh was found to be 11.6 nM for CSNPs prepared at 0.15 wt % ZnCl 2 concentration. Electrochemical investigations performed using differential pulse voltammetry and cyclic voltammetry techniques displayed that the oxidation current of ACh was higher for CSNPs synthesized at 0.15 wt % of ZnCl 2 concentration. We also demonstrate that the detection limit of ACh could be significantly improved by controlling the thickness of outermost shell layer. A detailed discussion on the mechanism of core–shell formation and the role of ZnCl 2 in the core–shell formation is reported. The size, composition, porosity, and morphology of CSNPs were characterized by using scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, Brunauer–Emmett–Teller (BET) surface area analysis, X-ray diffraction technique, and Fourier-transform infrared spectroscopy. An electrochemical approach with better specificity and detection limit for non-neurally secreted cancer biomarker, acetylcholine (ACh), by modifying the glassy carbon electrode surface with enzyme tagged ZnS/ZnO/Ta 2O 5–SiO 2 CSNPs is reported. We report a methodology to fabricate unique three-layered ZnS/ZnO/Ta 2O 5 (core)–SiO 2 (shell) nanoparticles (CSNPs) with varying compositions of ZnS, ZnO, Ta 2O 5, and SiO 2 in their layers (i.e., gradient structures).
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